High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

Cardiovascular Diabetology

Original Investigation

Masanori Abe¹  Shuzo Takayama¹  Ryuichi Kawamoto²  Tomo Kusunoki²  Nobuyuki Ohtsuka³  Tateaki Katoh³  Yasuharu Tabara⁴  Katsuhiko Kohara⁴  Tetsuro Miki⁴ 

[1] Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;Geriatric Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;

关键词: Insulin Resistance;    Uric Acid;    Fast Blood Glucose;    Impaired Fasting Glucose;    High Molecular Weight Adiponectin;   

DOI  :  10.1186/1475-2840-9-87

 received in 2010-11-07, accepted in 2010-12-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Increased high-sensitivity C-reactive protein (hsCRP) levels are associated with MetS and its components. Changes in gamma-glutamyl transferase (GGT) levels in response to oxidative stress are also associated with MetS, and the levels could be modulated by hsCRP.MethodsFrom a single community, we recruited 822 men (mean age, 61 ± 14 years) and 1,097 women (63 ± 12 years) during their annual health examination. We investigated whether increased hsCRP and GGT levels are synergistically associated with MetS and insulin resistance evaluated by Homeostasis of model assessment of insulin resistance (HOMA-IR).ResultsOf these subjects, 141 men (17.2%) and 170 women (15.5%) had MetS. Participants with MetS had a higher hsCRP and GGT level than those without MetS in both genders, and the HOMA-IR increased significantly in correlation with an increase in hsCRP and GGT. In men, the adjusted odds ratios (95% confidence interval) for MetS across tertiles of hsCRP and GGT were 1.00, 1.69 (1.01-2.80), and 2.13 (1.29-3.52), and 1.00, 3.26 (1.84-5.78) and 6.11 (3.30-11.3), respectively. In women, the respective corresponding values were 1.00, 1.54 (0.92-2.60), and 3.08 (1.88-5.06), and 1.00, 1.70 (1.04-2.79) and 2.67 (1.66-4.30). The interaction between increased hsCRP and GGT was a significant and independent determinant for MetS and insulin resistance in both genders.ConclusionsThese results suggested that higher CRP and GGT levels were synergistically associated with MetS and insulin resistance, independently of other confounding factor in the general population.

【 授权许可】

CC BY   
© Kawamoto et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.