Normal ranges of left ventricular strain in children: a meta-analysis

Cardiovascular Ultrasound

Review

Annika Rydberg¹  Lindita Kryeziu²  Fisnik Jashari³  Pranvera Ibrahimi³  Michael Y. Henein³  Gani Bajraktari³  Haki Jashari³ 

[1] Department of Clinical Sciences, Umeå University, Umeå, Sweden;Department of Neonatology, Gynecology Clinic, University Clinical Center of Kosovo, Prishtina, Kosovo;Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden;

关键词: Strain;    Echocardiography;    Children;    Left ventricle;   

DOI  :  10.1186/s12947-015-0029-0

 received in 2015-06-15, accepted in 2015-07-20,  发布年份 2015

来源: Springer

【 摘 要 】

AimsThe definition of normal values of two-dimensional speckle-tracking echocardiography derived left ventricular (LV) deformation parameters, is of critical importance for the routine application of this modality in children. The objectives of this study were to perform a meta-analysis of normal ranges for longitudinal, circumferential and radial strain/strain rate values and to identify confounders that may contribute to differences in reported measures.Methods and ResultsA systematic search was conducted. Studies describing normal healthy subjects and observational studies that used control groups as a comparison were included. Data were combined using a random-effect model. Effects of demographic, clinical and equipment variables were assessed through meta-regression. The search identified 1,192 subjects form 28 articles. Longitudinal strain (LS) normal mean values varied from -12.9 to -26.5 (mean, -20.5; 95% CI, -20.0 to -21.0). Normal mean values of circumferential strain (CS) varied from -10.5 to -27.0 (mean, -22.06; 95% CI, -21.5 to -22.5). Radial strain (RS) normal mean values varied from 24.9 to 62.1 (mean, 45.4; 95% CI, 43.0 to 47.8). Meta-regression showed LV end diastolic diameter as a significant determinant of variation for LS. Longitudinal systolic strain rate (LSRs) was significantly determined by the age and RS by the type of vendor used.ConclusionVariations among different normal ranges were dependent on the vendor used, LV end-diastolic diameter and age. Vendor-independent software for analyzing myocardial deformation in children, using images from different vendors would be the ideal solution for strain measurements or else using the same system for patient’s follow up.

【 授权许可】

Unknown   
© Jashari et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.