Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

Malaria Journal

Research

Martin C. Akogbeto¹  Sylvie Cornélie¹  Martin Donnelly²  Immo Kleinschmidt³  John Bradley³  Patrick Makoutode⁴  Filémon T. Tokponnon⁴  Alioun Adechoubou⁴  Thibaut Legba⁴  Jacob Fassinou⁵  Adicath Adéola Adéothy⁵  Aurore Ogouyèmi-Hounto⁵  Achille Massougbodji⁵  Yolande Sissinto Savi de Tove⁵  Dorothée Kinde-Gazard⁵  Telesphore Houansou⁶  Tessa Bellamy Knox⁶ 

[1] Institut Régional de développement/Centre de Recherche Entomologique de Cotonou, Cotonou, Benin;Liverpool School of Tropical Medicine, Liverpool, UK;MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;Programme National de Lutte contre le paludisme Cotonou, Cotonou, Benin;Unité d’Enseignement et de Recherche en Parasitologie-Mycologie de la Faculté des Sciences de la Santé de Cotonou, Cotonou, Benin;World Health Organization, Geneva, Switzerland;

关键词: Malaria;    Insecticide;    Pyrethroid;    Resistance;    Nets;   

DOI  :  10.1186/s12936-017-1873-1

 received in 2017-01-05, accepted in 2017-05-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMalaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa.MethodsIn 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children.ResultsChildren who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999).ConclusionsLLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.

【 授权许可】

CC BY   
© The Author(s) 2017