Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin

Malaria Journal

Abraham Peter Mnzava¹  Martin C. Akogbeto²  Martin J. Donnelly³  Yolande Sissinto⁴  Aurore Hounto Ogouyémi⁴  Dorothée Kinde-Gazard⁴  Achille Massougbodji⁴  Tessa B. Knox⁵  John Bradley⁶  Immo Kleinschmidt⁶  Sylvie Cornelie⁷  Vincent Corbel⁷  Mariam Oke⁸  Adicath Adéola Adéothy⁸  Alioun Adechoubou⁸  Filémon T. Tokponnon⁸  Télesphore Houansou⁹ 

[1] African Leaders Malaria Alliance (ALMA);Centre de Recherche Entomologique de Cotonou (CREC);Department of Vector Biology, Liverpool School of Tropical Medicine;Faculté des Sciences de la Santé de l’Université d’Abomey Calavi;Global Malaria Programme, WHO;MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine;Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), Institut de Recherche pour le Développement (IRD), CNRS, University of Montpellier;National Malaria Control Programme;World Health Organization;

关键词: Malaria;    Insecticide;    Pyrethroid;    Resistance;    Vector;   

DOI  :  10.1186/s12936-019-2656-7

来源: DOAJ

【 摘 要 】

Abstract Background Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria. Methods In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old. Results There was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777). Conclusions This study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa’s unacceptably high malaria burden.

【 授权许可】

Unknown