Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure

Reproductive Biology and Endocrinology

Research

Vesa Kotila¹  Ilkka Järvelä²  Maarit Niinimäki²  Anne Talvensaari-Mattila²  Ritva Nissi²  Taina Turpeenniemi-Hujanen³ 

[1] Department of Electrical Engineering, Division of Mathematics, University of Oulu, Finland;Department of Obstetrics and Gynecology, Oulu University Hospital, Kajaanintie 52A, 90220, Oulu, Finland;Department of Oncology and Radiotherapy, Oulu University Hospital, Kajaanintie 52A, 90220, Oulu, Finland;

关键词: MMP-2;    MMP-9;    TIMP-1;    TIMP-2;    Pregnancy;    Pregnancy loss;    Serum marker;    Placentation;   

DOI  :  10.1186/1477-7827-11-2

 received in 2012-10-14, accepted in 2013-01-02,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundTrophoblast cell (CTB) invasion into the maternal endometrium plays a crucial role during human embryo implantation and placentation. This invasion is facilitated by the activity of matrix metalloproteinases, which are regulated by tissue inhibitors of MMPs (TIMPs).MethodsThis study compares the serum levels of MMP-9, MMP-2/TIMP-2 complex, TIMP-1 and TIMP-2 in 129 patients with ongoing pregnancy (n = 40) or spontaneous early pregnancy failure (n = 89).ResultsMMP-9 was markedly (p < 0.0001) elevated in missed abortions, as was MMP-2/TIMP-2 complex (p < 0.0005). However, the serum levels of TIMP-1 and TIMP-2 were markedly elevated (p < 0.0001) in ongoing pregnancies.ConclusionsHuman placentation is mediated by fetal trophoblastic cells that invade the maternal uterine endometrium. Trophoblast invasion requires a precisely regulated secretion of specific proteolytic enzymes able to degrade the endometrial basement membrane and extracellular matrix. The elevated levels of MMP-9 and MMP-2/TIMP-2 complex may play a role in spontaneous termination of pregnancy.

【 授权许可】

CC BY   
© Nissi et al.; licensee BioMed Central Ltd. 2013