Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure

Reproductive Biology and Endocrinology

Taina Turpeenniemi-Hujanen¹  Ilkka Järvelä³  Maarit Niinimäki³  Vesa Kotila²  Anne Talvensaari-Mattila³  Ritva Nissi³ 

[1] Department of Oncology and Radiotherapy, Oulu University Hospital, Kajaanintie 52A, Oulu, 90220, Finland;Department of Electrical Engineering, Division of Mathematics, University of Oulu, Finland;Department of Obstetrics and Gynecology, Oulu University Hospital, Kajaanintie 52A, Oulu, 90220, Finland

关键词: Placentation;    Serum marker;    Pregnancy loss;    Pregnancy;    TIMP-2;    TIMP-1;    MMP-9;    MMP-2;   

Others  :  1149557
DOI  :  10.1186/1477-7827-11-2

 received in 2012-10-14, accepted in 2013-01-02,  发布年份 2013

【 摘 要 】

Background

Trophoblast cell (CTB) invasion into the maternal endometrium plays a crucial role during human embryo implantation and placentation. This invasion is facilitated by the activity of matrix metalloproteinases, which are regulated by tissue inhibitors of MMPs (TIMPs).

Methods

This study compares the serum levels of MMP-9, MMP-2/TIMP-2 complex, TIMP-1 and TIMP-2 in 129 patients with ongoing pregnancy (n = 40) or spontaneous early pregnancy failure (n = 89).

Results

MMP-9 was markedly (p < 0.0001) elevated in missed abortions, as was MMP-2/TIMP-2 complex (p < 0.0005). However, the serum levels of TIMP-1 and TIMP-2 were markedly elevated (p < 0.0001) in ongoing pregnancies.

Conclusions

Human placentation is mediated by fetal trophoblastic cells that invade the maternal uterine endometrium. Trophoblast invasion requires a precisely regulated secretion of specific proteolytic enzymes able to degrade the endometrial basement membrane and extracellular matrix. The elevated levels of MMP-9 and MMP-2/TIMP-2 complex may play a role in spontaneous termination of pregnancy.

【 授权许可】

   
2013 Nissi et al.; licensee BioMed Central Ltd.

【 图 表 】

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