Serum TGF-β1 and SMAD3 levels are closely associated with coronary artery disease

BMC Cardiovascular Disorders

Research Article

Congxin Huang¹  Can Chen²  Wenjiang Chen³  Bo Li³  Xiaoxin Gao³  Huailong Wang³  Jianfeng Zhong³  Wei Lei³ 

[1] Department of Cardiovascular Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, China;Department of Cardiovascular Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, China;Department of Cardiovascular Medicine, The Affiliated Hospital of Guangdong Medical College, 524000, Zhanjiang, China;Department of Cardiovascular Medicine, The Affiliated Hospital of Guangdong Medical College, 524000, Zhanjiang, China;

关键词: Coronary artery disease;    TGF-β1;    SMAD3 protein;    Human;    Biomarkers;   

DOI  :  10.1186/1471-2261-14-18

 received in 2013-10-23, accepted in 2014-02-11,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundCoronary artery disease (CAD) is one of the most common diseases leading to mortality and morbidity worldwide. There is considerable debate on whether serum transforming growth factor β1 (TGF-β1) levels are associated with long-term major adverse cardiovascular events in patients with CAD, and to date, no study has specifically addressed levels in patients with different degrees of CAD severity.MethodsSerum TGF-β1 and mothers against decapentaplegic homolog 3 (SMAD3) concentrations were evaluated in 279 patients with CAD and 268 controls without CAD. The clinical and biochemical characteristics of all subjects were also determined and analyzed.ResultsTGF-β1 and SMAD3 concentrations in CAD patients were significantly higher than those in the controls. The serum TGF-β1 level in acute myocardial infarction (AMI) was significantly higher than that in both stable angina pectoris (SAP) and unstable angina pectoris (UAP) (p < 0.05), while there was no marked difference between levels in SAP and UAP (p > 0.05). SMAD3 levels showed no obvious difference among AMI, SAP, and UAP. TGF-β1 and SMAD3 are potential biomarkers for CAD, and may be more accurate than Lpa, ApoA1, uric acid, BUN, or triglycerides (TG).ConclusionsSerum TGF-β1 and SMAD3 levels are closely associated with CAD, and may become useful biomarkers for diagnosis and risk stratification.

【 授权许可】

Unknown   
© Chen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.