Bladder metastasis from lung adenocarcinoma: a difficult differential diagnosis with primary bladder adenocarcinoma

World Journal of Surgical Oncology

Case Report

Pantaleo Bufo¹  Giuseppe Liuzzi¹  Giuseppe Carrieri¹  Luigi Cormio¹  Paolo Massenio¹  Francesca Sanguedolce¹  Giuseppe Di Fino¹ 

[1] Department of Urology and Renal Transplantation and Department of Pathology, University of Foggia, Viale L. Pinto 1, 71121, Foggia, Italy;

关键词: Urinary bladder;    Lung cancer;    Adenocarcinoma;    Metastasis;   

DOI  :  10.1186/1477-7819-12-90

 received in 2013-09-04, accepted in 2014-03-15,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundBladder metastases from lung adenocarcinoma are extremely rare; in the seven previously reported cases, the finding of an intact epithelium overlying the bladder tumour was considered suggestive of a secondary lesion. We describe the first case of bladder metastasis from lung adenocarcinoma whereby endoscopic appearance was strongly consistent with primary bladder cancer, thus complicating the differential diagnosis with primary bladder adenocarcinoma.Case reportA 65-year-old woman with a 13-year history of clean intermittent catheterization was diagnosed with a right lung adenocarcinoma metastatic to mediastinal and right supraclavicular nodes, as well as to the left lung, and treated with six cycles of cisplatin/pemetrexed, followed by six cycles of pemetrexed only. The 18-month follow-up computed tomography revealed several solid lesions of the bladder wall and she was scheduled for transurethral resection of bladder tumours. Endoscopic appearance was strongly consistent with primary bladder cancer but a thorough pathologic evaluation allowed the diagnosis of bladder metastasis from lung adenocarcinoma.ConclusionsDifferentiating primary bladder adenocarcinoma from metastatic adenocarcinoma lesions can be difficult. An endoscopic appearance consistent with primary bladder cancer further complicates the differential diagnosis, which heavily relies on pathologic evaluation and specific immunohistochemical staining.

【 授权许可】

CC BY   
© Cormio et al.; licensee BioMed Central Ltd. 2014