Bladder metastasis from lung adenocarcinoma: a difficult differential diagnosis with primary bladder adenocarcinoma

World Journal of Surgical Oncology

Giuseppe Carrieri¹  Pantaleo Bufo¹  Giuseppe Liuzzi¹  Paolo Massenio¹  Giuseppe Di Fino¹  Francesca Sanguedolce¹  Luigi Cormio¹ 

[1] Department of Urology and Renal Transplantation and Department of Pathology, University of Foggia, Viale L. Pinto 1, 71121 Foggia, Italy

关键词: Metastasis;    Adenocarcinoma;    Lung cancer;    Urinary bladder;   

Others  :  819971
DOI  :  10.1186/1477-7819-12-90

 received in 2013-09-04, accepted in 2014-03-15,  发布年份 2014

【 摘 要 】

Background

Bladder metastases from lung adenocarcinoma are extremely rare; in the seven previously reported cases, the finding of an intact epithelium overlying the bladder tumour was considered suggestive of a secondary lesion. We describe the first case of bladder metastasis from lung adenocarcinoma whereby endoscopic appearance was strongly consistent with primary bladder cancer, thus complicating the differential diagnosis with primary bladder adenocarcinoma.

Case report

A 65-year-old woman with a 13-year history of clean intermittent catheterization was diagnosed with a right lung adenocarcinoma metastatic to mediastinal and right supraclavicular nodes, as well as to the left lung, and treated with six cycles of cisplatin/pemetrexed, followed by six cycles of pemetrexed only. The 18-month follow-up computed tomography revealed several solid lesions of the bladder wall and she was scheduled for transurethral resection of bladder tumours. Endoscopic appearance was strongly consistent with primary bladder cancer but a thorough pathologic evaluation allowed the diagnosis of bladder metastasis from lung adenocarcinoma.

Conclusions

Differentiating primary bladder adenocarcinoma from metastatic adenocarcinoma lesions can be difficult. An endoscopic appearance consistent with primary bladder cancer further complicates the differential diagnosis, which heavily relies on pathologic evaluation and specific immunohistochemical staining.

【 授权许可】

   
2014 Cormio et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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【 参考文献 】

• [1]Ginsberg MS, Grewal RK, Heelan RT: Lung cancer. Radiol Clin North Am 2007, 45:21-43.
• [2]Martin-Marquina Aspiunza A, Diez-Caballero Alonso F, Rodriguez-Rubio Cortadellas FI, Díez Fernández L, Abad Vivas-Pérez JI, Rosell Costa D, Robles García JE, Zudaire Bergera JJ, Berián Polo JM: Bladder metastasis of lung adenocarcinoma. Actas Urol Esp 1997, 21:406-8.
• [3]Bates AW, Baithun SI: Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: clinico-pathological and histological features of 282 cases. Histopathology 2000, 36:32-40.
• [4]Raspollini MR, Comin CE, Crisci A, Chilosi M: The use of placental S100 (S100P), GATA3 and napsin A in the differential diagnosis of primary adenocarcinoma of the bladder and bladder metastasis from adenocarcinoma of the lung. Pathologica 2010, 102:33-35.
• [5]Sakhri L, Mennecier B, Jacqmin D, Di Marco A, Schumacher C, Chenard MP, Bergmann E, Quoix E: Atypical metastatic site of lung adenocarcinoma. Rev Pneumol Clin 2011, 67:375-379.
• [6]Shirakawa H, Kozakai N, Sawafuji M, Sugiura H, Hara S: Urinary bladder metastasis originating from lung adenocarcinoma: a case definitively diagnosed by immunohistochemistry. Urol J 2012, 9:530-532.
• [7]Karle W, Barazani Y, Tareen B: A rare case of metastatic lung cancer to the bladder. Can Urol Assoc J 2012, 6:E147-E149.
• [8]Modh RA, Corbyons KA, Yeung LL: A rare metastasis to the bladder. Case Rep Urol 2013, 2013:789039.