New treatments for influenza

BMC Medicine

Review

Sailen Barik¹ 

[1] Center for Gene Regulation in Health and Disease, Cleveland State University, 2351 Euclid Avenue, 44115, Cleveland, Ohio, USA;Department of Biological, Geological and Environmental Sciences, Cleveland State University, 2121 Euclid Avenue, 44115, Cleveland, Ohio, USA;

关键词: Cathelicidin;    defensin;    influenza;    hemagglutinin;    neuraminidase;    NSAID;    oseltamivir;    siRNA;    zanamivir;   

DOI  :  10.1186/1741-7015-10-104

 received in 2012-04-24, accepted in 2012-09-13,  发布年份 2012

来源: Springer

【 摘 要 】

Influenza has a long history of causing morbidity and mortality in the human population through routine seasonal spread and global pandemics. The high mutation rate of the RNA genome of the influenza virus, combined with assortment of its multiple genomic segments, promote antigenic diversity and new subtypes, allowing the virus to evade vaccines and become resistant to antiviral drugs. There is thus a continuing need for new anti-influenza therapy using novel targets and creative strategies. In this review, we summarize prospective future therapeutic regimens based on recent molecular and genomic discoveries.

【 授权许可】

CC BY   
© Barik; licensee BioMed Central Ltd. 2012