Small dense low-density lipoprotein cholesterol was associated with future cardiovascular events in chronic kidney disease patients

BMC Nephrology

Research Article

Guorong Shen¹  Chunfang Ma¹  Jingfen Lu¹  Qiong Li¹  Hao Shen¹  Xu Chen¹  Yadong Zhou¹  Ao Zhu²  Yan Xu³ 

[1] Department of Clinical Laboratory Medicine, First People’s Hospital of Wujiang District, Nantong University, Suzhou, China;Department of Geriatrics, First People’s Hospital of Wujiang District, Nantong University, Suzhou, China;Department of Nephrology, First People’s Hospital of Wujiang District, Nantong University, Suzhou, China;

关键词: Chronic kidney disease;    Cardiovascular diseases;    Lipids;    sdLDL-C;   

DOI  :  10.1186/s12882-016-0358-8

 received in 2016-06-28, accepted in 2016-09-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCardiovascular disease (CVD) is often comorbid with chronic kidney disease (CKD). Small low-density lipoprotein cholesterol (sdLDL-C) has also been found to increase risk for CVD. The goal of the present study was to determine the nature of the relationship between sdLDL-C concentration and CVD in patients with CKD.MethodsOne-hundred and forty-five subjects (113 men and 32 women) with CKD (Stage 3 and Stage 4) participated this retrospective study. The concentration of sdLDL-C was measured in samples from 145 CKD patients between 2010 and 2012 during a four-year follow-up period.ResultsA total of eight fatal cardiovascular events (CVs) and 46 nonfatal CVs were registered in the four-year follow-up period. Multivariate Cox regression analysis showed that sdLDL-C [1.278, 95 % (1.019–1.598)] and sdLDL-C/LDL-C [2.456, 95 % (1.421–15.784)], at final observation, were independent risks of CVs. A Kaplan-Meier survival analysis showed that patients with sdLDL-C >38 mg/dl (logrank: 4.375, P = 0.037), and sdLDL-C/LDL-C ratio >0.3 levels (logrank: 11.94, P = 0.018) were at increased risk for CVs.ConclusionThe results of this study indicated that for patients suffering CKD, a significant relationship exists between an elevated sdLDL-C concentration and the risk of cardiovascular disease.

【 授权许可】

CC BY   
© The Author(s). 2016