Functional role of post-translational modifications of Sp1 in tumorigenesis

Journal of Biomedical Science

Review

Jan-Jong Hung¹  Wen-Chang Chang² 

[1] Institute of Basic Medical Sciences, College of Medicine, National Cheng-Kung University, 701, Tainan, Taiwan;Department of Pharmacology, College of Medicine, National Cheng-Kung University, 701, Tainan, Taiwan;Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, 701, Tainan, Taiwan;Center for Infection Diseases and Signal Transduction Research, National Cheng-Kung University, 701, Tainan, Taiwan;Institute of Basic Medical Sciences, College of Medicine, National Cheng-Kung University, 701, Tainan, Taiwan;Department of Pharmacology, College of Medicine, National Cheng-Kung University, 701, Tainan, Taiwan;Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, 701, Tainan, Taiwan;Center for Infection Diseases and Signal Transduction Research, National Cheng-Kung University, 701, Tainan, Taiwan;Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan;

关键词: Ataxia Telangiectasia Mutate;    Betulinic Acid;    Arsenic Trioxide;    Tolfenamic Acid;    RECK Gene Expression;   

DOI  :  10.1186/1423-0127-19-94

 received in 2012-09-25, accepted in 2012-10-03,  发布年份 2012

来源: Springer

【 摘 要 】

Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. Recent studies found that an increase in Sp1 transcriptional activity is associated with the tumorigenesis. Moreover, post-translational modifications of Sp1, including glycosylation, phosphorylation, acetylation, sumoylation, ubiquitination, and methylation, regulate Sp1 transcriptional activity and modulate target gene expression by affecting its DNA binding activity, transactivation activity, or protein level. In addition, recent studies have investigated several compounds with anti-cancer activity that could inhibit Sp1 transcriptional activity. In this review, we describe the effect of various post-translational modifications on Sp1 transcriptional activity and discuss compounds that inhibit the activity of Sp1.

【 授权许可】

CC BY   
© Chang and Hung; licensee BioMed Central Ltd. 2012