Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum

Lipids in Health and Disease

Research

Anna Haug¹  Arne Torbjørn Høstmark² 

[1] Department of Animal and Aquacultural Sciences, The Norwegian University of Life Sciences, Box 5003, 1432, Ås, Norway;Institute of Health and Society, Section of Preventive Medicine and Epidemiology, University of Oslo, Norway, Box 1130, 0318, Blindern, Oslo, Norway;

关键词: Oleic Acid;    Arachidonic Acid;    Multiple Linear Regression Model;    Myristic Acid;    Standardize Regression Coefficient;   

DOI  :  10.1186/1476-511X-12-40

 received in 2013-01-09, accepted in 2013-03-21,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundSince many health effects of oils rich in oleic acid (18:1, n-9) seem to be opposite those of arachidonic acid (20:4, n-6), i.e. concerning cardiovascular risk, we examined whether % 18:1 might be negatively associated with % 20:4.MethodsFatty acid separation by gas chromatography was performed in total serum lipids of 36 male rats. Using bivariate correlations and multiple linear regressions we studied the association between oleic acid and arachidonic acid.ResultsWe found an inverse relationship (r = -0.885, p < 0.001; n = 36) between percentages of 18:1 and 20:4 in total lipids of rat serum, persisting when controlling for the other fatty acids measured. In a multiple linear regression model with % 20:4 as the dependent variable and percentages of the other fatty acids entered simultaneously as independents, oleic acid and linoleic acid contributed most to predict % 20:4. Per cent 20:4 correlated negatively (p< 0.01) with a Delta-9 desaturase index, i.e. the (18:1)/(18:0) ratio, and %18:1 with the (20:4)/(18:2) ratio, estimating desaturases/elongase.ConclusionsPercentages of 18:1 and 20:4 seem to be inversely related and desaturase/elongase inhibition could be involved. The results might partly explain positive health effects of foods rich in oleic acid.

【 授权许可】

CC BY   
© Høstmark and Haug; licensee BioMed Central Ltd. 2013