Irvingia gabonensis fat: nutritional properties and effect of increasing amounts on the growth and lipid metabolism of young rats wistar sp

Lipids in Health and Disease

Research

Linder Michel¹  Jacques Fanni¹  Thierry Joël Nangue²  Felicite Tchouanguep Mbiapo²  Hilaire Macaire Womeni² 

[1] Laboratory of Biomolecular Engineering (lIbio), National School of Agronomy and Food Industries ENSAIA - INPL, BP 172 F-54505, 2 Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy, France;Laboratory of Food Sciences Nutrition and Medicinal Plant, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. BOX: 67, Cameroon;

关键词: Saturated Fatty Acid;    Lauric Acid;    Cholesteryl Ester Transfer Protein;    Myristic Acid;    Female Group;   

DOI  :  10.1186/1476-511X-10-43

 received in 2010-12-11, accepted in 2011-03-04,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundDietary saturated fatty acids (SFAs) are generally considered to increase plasma cholesterol. It has also been claimed that they increase cardio-vascular disease, although the claim that some of SFAs can increase HDL-cholesterol is poorly documented. Irvingia gabonensis kernels after being dried and crushed they are generally used to prepare a sticky and aromatic soup very much consumed in Cameroun and West Africa countries. This study was therefore aimed at evaluating the effects of dika nut fat on the growing and lipids metabolism of young rats.MethodFor The nutritional evaluation related to the performances of growth and the analysis of increasing amounts of dika nut fat (0; 5.1; 7.34 and 13.48%) in young rats of wistar sp. The animals were taken individually out of metabolic cage for each ration 5 repetitions per sex (males and females) were carried out.ResultsThe results obtained during the 3 weeks of treatment shows that the performances of consumption were positive. A highly significant increase (P < 0,01) of serum cholesterol and triglycerides in the high dose fat groups (13,48%) of dika fat were observed compared to control groups. However, this rise of cholesterol is due to that of HDL-cholesterol without any change in the quantity of LDL-Receptor. In parallel, the weight of the vital organ did not vary much compared to control, except for males where we observed a significantly reduction (P < 0,01) in the weight of the liver for the three diet tests.ConclusionThis study shows that the increasing amount of dika nut fat alter significantly cholesterol and triglyceride at high dose diet, but also increase HDL-cholesterol.

【 授权许可】

CC BY   
© Nangue et al; licensee BioMed Central Ltd. 2011