Sex- and age-differences in blood manganese levels in the U.S. general population: national health and nutrition examination survey 2011–2012

Environmental Health

Research

Donna Mergler¹  Youssef Oulhote²  Maryse F Bouchard² 

[1] CINBIOSE, Université du Québec à Montréal, Montréal, Canada;Department of Environmental and Occupational Health, Université de Montréal, Montréal, Canada;CHU Sainte-Justine Research Center, Montréal, Canada;

关键词: Blood manganese;    Sex;    Age;    Population survey;    NHANES;   

DOI  :  10.1186/1476-069X-13-87

 received in 2014-07-21, accepted in 2014-10-17,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundManganese is an essential element, but excessive manganese exposure has neurotoxic effects.ObjectiveTo examine blood manganese levels in the general population with respect to sex, age, race/ethnicity, pregnancy and menauposal status, as well as levels of trace elements in blood.MethodsWe used data from the National Health and Nutrition Examination Survey, a national survey of U.S. residents (n = 7720 participants, ages 1 to 80 years). General linear models and generalized additive models were used to examine the association between blood manganese concentration and participants’ characterisics, accounting for the complex survey design.ResultsBlood manganese levels ranged from 1.6 to 62.5 μg/L, with arithmetic means of 10.6 and 9.2 μg/L for women and men, respectively. The following characteristics were significantly associated with higher blood manganese levels: female sex, younger age, Asian origin, and being pregnant. In addition, there were non-linear relationships between blood manganese levels and cadmium, iron, lead, and mercury levels.ConclusionThe higher blood manganese levels observed among females suggest sex-related metabolic differences in the regulation of manganese, and elevated levels among pregnant women suggest an important role of manganese in reproduction. The present study supports the need to take into consideration age- and sex-related differences in blood manganese levels, as well as pregnancy status when examining manganese essentiality or toxicity.

【 授权许可】

Unknown   
© Oulhote et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.