The association between leukocytes and sperm quality is concentration dependent

Reproductive Biology and Endocrinology

Research

Reda Mahfouz¹  Ashok Agarwal¹  Jakob E Lackner²  Georg Schatzl³  Stefan S du Plessis⁴ 

[1] Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Glickman Tower, Cleveland Clinic, Cleveland, Ohio, USA;Department of Urology, KH Hietzing mit Neurologischem Zentrum Rosenhügel & Ludwig Boltzmann Institut für Andrologie und Urologie, Vienna, Austria;Department of Urology, Medical University of Vienna, Vienna, Austria;Division of Medical Physiology, University of Stellenbosch, South Africa;

关键词: Reactive Oxygen Species;    Total Antioxidant Capacity;    Sperm Motility;    Semen Sample;    Normal Morphology;   

DOI  :  10.1186/1477-7827-8-12

 received in 2009-11-27, accepted in 2010-02-05,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundTo evaluate the association between leukocytes (polymorphonuclear granulocytes -PMNL) and semen parameters at different leukocyte concentrations.MethodsThis was a retrospective clinical study at a university hospital andrology clinic. Semen samples from infertile men were analyzed for sperm morphology and motility according to seminal leukocytes (PMNL) concentration (category A: >0 to <0.25 × 10(6)/mL; category B: >0.25 to <0.5 × 10(6)/mL; category C: >0.5 to <0.75 × 10(6)/mL; category D: >0.75 to <1.0 × 10(6)/mL, category E: >1 × 10(6)/mL).ResultsThe percentage of sperm with normal morphology increased significantly from category A (14%) to category D (19%) but decreased in category E to levels (14%) similar to those in category A. Motility grades a and a+b (combined) also increased from category A (12%, 20%) to category D (18.0%, 28.5%) and decreased in category E (11%, 20.5%) to levels similar to those in category A. Sperm deformities and motility grades c and d increased progressively in all categories.SummaryLeukocytes had a positive association with normal morphology and progressive motility in semen samples at a concentration of 0-1 × 10(6)/mL. The findings suggest that the association between leukocytes (PMNL) and semen quality might be concentration dependent.

【 授权许可】

CC BY   
© Lackner et al; licensee BioMed Central Ltd. 2010