Preventive effect of taurine on experimental type II diabetic nephropathy

Journal of Biomedical Science

Review

Qiufeng Lv¹  Gaofeng Wu¹  Xinhong Luan¹  Shumei Lin¹  Jiancheng Yang¹  He Zhao¹  Jianmin Hu¹  Mei Liu¹ 

[1] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, 110866, Shenyang, P.R. China;

关键词: Taurine;    Diabetic Nephropathy;    Glomerular Basement Membrane;    Random Blood Glucose;    Decrease Blood Glucose;   

DOI  :  10.1186/1423-0127-17-S1-S46

来源: Springer

【 摘 要 】

BackgroundIt has been verified that taurine has some preventive effects on diabetes and its complications when used alone or together with other drugs, but there are few reports about taurine on the prevention of diabetic nephropathy, the mechanisms of which are still unknown.MethodsTaurine was administered to type II diabetic rats induced by high fat high sugar diet combined with STZ injection. The preventive effect of taurine on diabetic nephropathy was investigated by detecting blood glucose, lipid metabolism, kidney function and glomerular basement membrane metabolism.ResultsTaurine could lower blood glucose, TG, TC, BUN, Scr, NAG, U-PRO, the expression of laminin B1( LBN1) mRNA, and increase HDL-C of diabetic rats.ConclusionsThe results indicated that taurine could prevent the occurrence and development of diabetic nephropathy by decreasing blood glucose, improving lipid metabolism, glomerular basement membrane metabolism, and kidney function.

【 授权许可】

CC BY   
© Hu et al; licensee BioMed Central Ltd. 2010