Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?

World Journal of Surgical Oncology

Case Report

Saoussan Kharmoum¹  Zouhour Fadoukhair¹  Hassan Errihani¹  Ismail Essaidi¹  Mohammed Ichou²  Mohamed Oukabli²  Yassir Sbitti³  Hind M'rabti⁴  Habiba Kadiri⁵  Abderrahmane Albouzidi⁵ 

[1] Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco;Department of Medical Oncology, University Military Hospital, Rabat, Morocco;Department of Medical Oncology, University Military Hospital, Rabat, Morocco;Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco;Department of Pathology, Diagnostic Centre, Rabat, Morocco;Department of Pathology, University Military Hospital, Rabat, Morocco;

关键词: melanoma;    ovarian neoplasm;    secondary;    differential diagnosis;   

DOI  :  10.1186/1477-7819-9-65

 received in 2010-10-07, accepted in 2011-06-17,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundIn the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer.Case reportA 45-year-old premenopausal woman was incidentally found to have an abdominal mass, 3 years after removal of a cutaneous melanoma lesion. Ultrasound and CT scan revealed left two solid masses, which were found to be an ovarian tumor at laparotomy. Left oophorectomy was performed. Histopathology and immunohistochemistry showed melanoma metastasis to the ovary. Nine months later, the patient developed epilepsy and confusion. Magnetic Resonance Imaging showed unique Wright frontal lobe lesion. She underwent stereotactic radio surgery and dacarbazine monotherapy. For months later, the patient is died from disseminate disease progression.ConclusionOvarian metastasis is an unusual presentation of cutaneous melanoma and the prognosis was dismal. As illustrated by this case report, a differential diagnosis of a metastatic malignant melanoma must be considered.

【 授权许可】

CC BY   
© Sbitti et al; licensee BioMed Central Ltd. 2011