Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?

World Journal of Surgical Oncology

Hassan Errihani⁴  Mohammed Ichou¹  Abderrahmane Albouzidi³  Hind M'rabti²  Saoussan Kharmoum⁴  Ismail Essaidi⁴  Mohamed Oukabli¹  Habiba Kadiri³  Zouhour Fadoukhair⁴  Yassir Sbitti⁴ 

[1] Department of Medical Oncology, University Military Hospital, Rabat, Morocco;Department of Pathology, Diagnostic Centre, Rabat, Morocco;Department of Pathology, University Military Hospital, Rabat, Morocco;Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco

关键词: differential diagnosis;    secondary;    ovarian neoplasm;    melanoma;   

Others  :  1206700
DOI  :  10.1186/1477-7819-9-65

 received in 2010-10-07, accepted in 2011-06-17,  发布年份 2011

【 摘 要 】

Background

In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer.

Case report

A 45-year-old premenopausal woman was incidentally found to have an abdominal mass, 3 years after removal of a cutaneous melanoma lesion. Ultrasound and CT scan revealed left two solid masses, which were found to be an ovarian tumor at laparotomy. Left oophorectomy was performed. Histopathology and immunohistochemistry showed melanoma metastasis to the ovary. Nine months later, the patient developed epilepsy and confusion. Magnetic Resonance Imaging showed unique Wright frontal lobe lesion. She underwent stereotactic radio surgery and dacarbazine monotherapy. For months later, the patient is died from disseminate disease progression.

Conclusion

Ovarian metastasis is an unusual presentation of cutaneous melanoma and the prognosis was dismal. As illustrated by this case report, a differential diagnosis of a metastatic malignant melanoma must be considered.

【 授权许可】

   
2011 Sbitti et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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