期刊论文详细信息
Lipids in Health and Disease
Perilipins: a diversity of intracellular lipid droplet proteins
Review
Hiroyuki Itabe1  Naoko Sasabe1  Satomi Nimura2  Tomohiro Yamaguchi3 
[1] Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa, 142-8555, Tokyo, Japan;Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa, 142-8555, Tokyo, Japan;Department of Hospital Pharmaceutics, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa, 142-8555, Tokyo, Japan;Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa, 142-8555, Tokyo, Japan;Present address: College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyaka-ku, 463-8521, Nagoya, Japan;
关键词: Perilipin;    Lipid droplet;    Hydroxysteroid dehydrogenase;   
DOI  :  10.1186/s12944-017-0473-y
 received in 2017-02-24, accepted in 2017-04-22,  发布年份 2017
来源: Springer
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【 摘 要 】

Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they are active sites of neutral lipid metabolism, and comprise neutral lipid or cholesterol cores surrounded by phospholipid monolayers containing specialized proteins. However, sizes and protein compositions vary between cell and tissue types. Proteins of the perilipin family have been associated with surfaces of LDs and all carry a conserved 11-mer repeat motif. Accumulating evidence indicates that all perilipins are involved in LD formation and that all play roles in LD function under differing conditions. In this brief review, we summarize current knowledge of the roles of perilipins and lipid metabolizing enzymes in a variety of mammalian cell types.

【 授权许可】

CC BY   
© The Author(s). 2017

【 预 览 】
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