Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

Journal of Nanobiotechnology

Research

Jiahui Hou¹  Liang Zhao¹  Yijie Shi¹  Tao Wang¹  Chang Su² 

[1] School of Pharmacy, Jinzhou Medical University, 121000, Jinzhou, People’s Republic of China;School of Veterinary Medicine, Jinzhou Medical University, 121000, Jinzhou, People’s Republic of China;

关键词: Nanoparticles;    Hyaluronic acid;    CD44;    Mitochondria;    Reactive oxygen species;   

DOI  :  10.1186/s12951-016-0245-2

 received in 2016-10-28, accepted in 2016-12-30,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundA targeted drug nanoparticle (NP) delivery system has shown potential as a possible cancer treatment. Given its merits, such as its selective distribution at tumor sites and its controllable drug release, drug-loaded NPs can be effectively delivered to selected organs and targeted cells, thus enhancing its antitumor efficiency and reducing its toxicity.MethodsWe reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44.ResultsOur new findings suggested that HA-coated chitosan NPs enhanced drug accumulation by effectively transporting NPs into CD44-overexpressed tumor cells, and they also resulted in mitochondrial damage induced by the production of reactive oxygen species (ROS). Compared to free drug and uncoated NPs, HA-coated chitosan NPs exhibited stronger inhibition rates and induced obvious apoptosis in CD44-overexpressed A549 cells.ConclusionsBiocompatible and biodegradable HA-coated chitosan NPs were developed to encapsulate a chemotherapeutic drug (5-Fu) to enhance drug accumulation in tumor cells and to improve the agent’s antitumor efficiency by offering targeted drug delivery via CD44.

【 授权许可】

CC BY   
© The Author(s) 2017