Coverage of intermittent prevention treatment with sulphadoxine-pyrimethamine among pregnant women and congenital malaria in Côte d'Ivoire

Malaria Journal

Research

François Dabis¹  Caroline Sloan²  Serge Kanhon²  Didier K Ekouevi³  Patrick A Coffie³  Firmin Kouakou⁴  Serge P Eholie⁵  Moussa Kone⁶  Henriette A Vanga-Bosson⁶  Hervé Menan⁷ 

[1] Institut de Santé Publique, Epidémiologie et Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France;Centre INSERM U897, Université Victor Segalen Bordeaux 2, Bordeaux, France;Programme PAC-CI, Abidjan, Côte d'Ivoire;Programme PAC-CI, Abidjan, Côte d'Ivoire;Institut de Santé Publique, Epidémiologie et Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France;Centre INSERM U897, Université Victor Segalen Bordeaux 2, Bordeaux, France;Service de Gynécologie Obstétrique CHU de Cocody, Abidjan, Côte d'Ivoire;Service des Maladies Infectieuses et Tropicales, CHU de Treichville, Côte d'Ivoire;UFR des Sciences Pharmaceutiques et Biologiques, Abidjan, Côte d'Ivoire;UFR des Sciences Pharmaceutiques et Biologiques, Abidjan, Côte d'Ivoire;CeDReS, Centre Hospitalier Universitaire Treichville, Abidjan, Côte d'Ivoire;

关键词: Malaria;    Placental Malaria;    Intermittent Preventive Treatment;    Pharmacy Student;    Malaria Parasitaemia;   

DOI  :  10.1186/1475-2875-10-105

 received in 2010-12-10, accepted in 2011-04-29,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe World Health Organization (WHO) recommends using insecticide-treated mosquito nets (ITNs) and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) to prevent malaria in sub-Saharan Africa. Data on IPT-SP coverage and factors associated with placental malaria parasitaemia and low birth weight (LBW) are scarce in Côte d'Ivoire.MethodsA multicentre, cross-sectional survey was conducted in Côte d'Ivoire from March to September 2008 at six urban and semi-urban antenatal clinics. Standardized forms were used to collect the demographic information and medical histories of women and their offspring. IPT-SP coverage (≥2 doses) as well as placental and congenital malaria prevalence parasitaemia were estimated. Regression logistics were used to study factors associated with placental malaria and LBW (birth weight of alive babies < 2,500 grams).ResultsOverall, 2,044 women with a median age of 24 years were included in this study. Among them 1017 (49.8%) received ≥2 doses of IPT-SP and 694 (34.0%) received one dose. A total of 99 mothers (4.8%) had placental malaria, and of them, four cases of congenital malaria were diagnosed. Factors that protected from maternal placental malaria parasitaemia were the use of one dose (adjusted odds ratio (aOR), 0.32; 95%CI: 0.19-0.55) or ≥2 doses IPT-SP (aOR: 0.18; 95%CI: 0.10-0.32); the use of ITNs (aOR: 0.47; 95%CI: 0.27-0.82). LBW was associated with primigravidity and placental malaria parasitaemia.ConclusionIPT-SP decreases the rate of placental malaria parasitaemia and has a strong dose effect. Despite relatively successful IPT-SP coverage in Côte d'Ivoire, substantial commitments from national authorities are urgently required for such public health campaigns. Strategies, such as providing IPT-SP free of charge and directly observing treatment, should be implemented to increase the use of IPT-SP as well as other prophylactic methods.

【 授权许可】

Unknown   
© Vanga-Bosson et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.