ABO blood group and the risk of placental malaria in sub-Saharan Africa

Malaria Journal

Research

Maria Yazdanbakhsh¹  Martin P Grobusch²  Michael Ramharter³  Adrian JF Luty⁴  Peter G Kremsner⁵  Norbert G Schwarz⁶  Ayola A Adegnika⁷ 

[1] Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands;Infectious Diseases, Tropical Medicine and AIDS, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands;Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon;Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Austria;Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon;Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands;Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon;Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany;Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon;Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany;Bernhard Nocht Institute for Tropical Medicine, Infectious Disease Epidemiology Bernhard-Nocht Straße, 74D-20359, Hamburg, Germany;Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon;Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany;Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands;

关键词: Malaria;    Blood Group;    Infected Erythrocyte;    Placental Malaria;    Placental Infection;   

DOI  :  10.1186/1475-2875-10-101

 received in 2011-01-07, accepted in 2011-04-22,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundIn malarious areas of the world, a higher proportion of the population has blood group O than in non-malarious areas. This is probably due to a survival advantage conferred either by an attenuating effect on the course of or reduction in the risk of infection by plasmodial parasites. Here, the association between ABO blood group and incidence of placental malaria was assessed in order to determine the possible influence of the former on the latter.MethodsData from a study in Lambaréné, Gabon, and data from three previously published reports of studies in The Gambia, Malawi and Sudan, were compiled and compared. ABO blood groups were cross-tabulated with placental malaria stratified by parity. Odds ratios (OR), stratified by parity, were calculated for the outcome, placental parasitaemia, and compared between blood group O vs. non-O mothers in all four studies. Random effects meta-analysis of data from individual studies from areas with perennial hyper/holoendemic transmission was performed.ResultsIn Gabon, the odds ratio (OR) for active placental parasitaemia in mothers with group O was 0.3 (95% CI 0.05-1.8) for primiparae and 0.7 (95% CI 0.3-1.8) for multiparae. The OR for primiparae in the published study from The Gambia was 3.0 (95% CI 1.2-7.3) and, in Malawi, 2.2 (95% CI 1.1-4.3). In the Sudanese study, no OR for primiparae could be calculated. The OR for placental parasitaemia in group O multiparae was 0.8 (95% CI 0.3-1.7) in the Gambia, 0.6 (95% CI 0.4-1.0) in Malawi and 0.4 (95% CI 0.1-1.8) in Sudan. Combining data from the three studies conducted in hyper-/holo-endemic settings (Gambia, Malawi, Gabon) the OR for placental malaria in blood group O multiparae was 0.65 (95% CI 0.44-0.96) and for primiparae 1.70 (95% CI 0.67-4.33).ConclusionStudies conducted in The Gambia and Malawi suggest that blood group O confers a higher risk of active placental infection in primiparae, but a significantly lower risk in multiparae. These findings were not confirmed by the study from Gabon, in which statistically non-significant trends for reduced risk of placental parasitaemia in those with blood group O, regardless of parity, were observed.

【 授权许可】

Unknown   
© Adegnika et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.