Micro- and nanotechnology approaches for capturing circulating tumor cells

Cancer Nanotechnology

Review Article

Eric Wickstrom¹  Tom Burkhead²  Palaniappan Sethu²  Shesh N. Rai³  Goetz Kloecker⁴  L. Jay Stallons⁵  W. Glenn McGregor⁵  Vanessa Velasco⁶  Ben King⁶  James Loomis⁶  Peng Xu⁶  Robert Caprara⁶  Balaji Panchapakesan⁶ 

[1] Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, 19107, Philadelphia, PA, USA;Department of Bioengineering, University of Louisville, 40292, Louisville, KY, USA;Department of Bioinformatics & Biostatistics and Biostatistics Shared Facility, James Graham Brown Cancer Center, 505 S. Hancock Street, Room 211, 40202, Louisville, KY, USA;Department of Hematology and Oncology, James Graham Brown Cancer Center, University of Louisville, 40292, Louisville, KY, USA;Department of Pharmacology and Toxicology, University of Louisville, 40292, Louisville, KY, USA;Small Systems Laboratory, Department of Mechanical Engineering, University of Louisville, 40292, Louisville, KY, USA;

关键词: Circulate Tumor Cell;    Cell Capture;    Circulate Tumor Cell Detector;    Photoacoustic Detection;    Circulate Tumor Cell Count;   

DOI  :  10.1007/s12645-010-0007-z

 received in 2010-08-11, accepted in 2010-10-01,  发布年份 2010

来源: Springer

【 摘 要 】

Circulating tumor cells (CTC) are cells that have detached from primary tumors and circulate in the bloodstream where they are carried to other organs, leading to seeding of new tumors and metastases. CTC have been known to exist in the bloodstream for more than a century. With recent progress in the area of micro- and nanotechnology, it has been possible to adopt new approaches in CTC research. Microscale and nanoscale studies can throw some light on the time course of CTC appearance in blood and CTC overexpression profiles for cancer-related markers and galvanize the development of drugs to block metastases. CTC counts could serve as endpoint biomarkers and as prognostic markers for patients with a metastatic disease. This paper reviews some of the recent researches on using micro- and nanotechnology to capture and profile CTC.

【 授权许可】

Unknown   
© Springer-Verlag 2010