BEV-IP: Perioperative chemotherapy with bevacizumab in patients undergoing cytoreduction and intraperitoneal chemoperfusion for colorectal carcinomatosis

BMC Cancer

Study Protocol

Gabriel Liberale¹  Wouter Willaert²  Wim Ceelen²  Kurt Van Der Speeten³ 

[1] Clinic of Digestive Surgical Oncology, Jules Bordet Institute, Brussels, Belgium;Department of Gastrointestinal Surgery, Ghent University Hospital, 2K12 IC UZ De Pintelaan 185, B-9000, Ghent, Belgium;Department of Surgical Oncology, Oost-Limburg Hospital, Genk, Belgium;

关键词: Bevacizumab;    Colorectal cancer;    Cytoreductive surgery;    HIPEC;    Perioperative chemotherapy;    Peritoneal carcinomatosis;   

DOI  :  10.1186/s12885-015-1954-x

 received in 2015-07-08, accepted in 2015-11-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSelected patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) benefit from cytoreductive surgery (CRS) combined with intraperitoneal chemoperfusion (IPC). However, even after optimal cytoreduction, systemic and locoregional recurrence are common. Perioperative chemotherapy with bevacizumab (BEV) may improve the outcome of these patients.Methods/DesignThe BEV-IP study is a phase II, single-arm, open-label study aimed at patients with colorectal or appendiceal adenocarcinoma with synchronous or metachronous PC. This study evaluates whether perioperative chemotherapy including BEV in combination with CRS and oxaliplatin-based IPC results in acceptable morbidity and mortality (primary composite endpoint). Secondary endpoints are treatment completion rate, chemotherapy-related toxicity, pathological response, progression free survival, and overall survival.DiscussionThe BEV-IP trial is the first prospective assessment of the safety and efficacy of perioperative chemotherapy combined with anti-angiogenic treatment in patients undergoing CRS and IPC for colorectal peritoneal metastases.Trial registrationClinicalTrials.gov Identifier: NCT02399410 EudraCT number: 2015-001187-19 (registered March 9, 2015).

【 授权许可】

CC BY   
© Willaert et al. 2015