Modification of fatty acids composition in erythrocytes lipids in arterial hypertension associated with dyslipidemia

Lipids in Health and Disease

Review

Tatyana A Kantur¹  Marina V Antonyuk¹  Tatyana P Novgorodtseva¹  Yulia K Karaman¹  Natalia V Zhukova² 

[1] Vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration of SB RAMN - Institute of Medical Climatology and Rehabilitative Treatment, Russia;Zhirmunsky Institute of Marine Biology, Far East Branch of Russian Academy of Sciences, Vladivostok, Russia;

关键词: High Density Lipoprotein;    Saturated Fatty Acid;    Arterial Hypertension;    Atherogenicity Index;    Unsaturation Index;   

DOI  :  10.1186/1476-511X-10-18

 received in 2010-11-17, accepted in 2011-01-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundModification of fatty acids (FA) composition in erythrocytes lipids as an early indicator of the development of arterial hypertension (AH) and lipid disorders.MethodsWe included 34 patients with arterial hypertension and 11 healthy individuals. Each patient was examined the lipid composition of serum. From erythrocytes by gas chromatography were identified fatty acids. The quantitative composition of the erythrocyte lipids FA in patients with AH presented with saturated and polyunsaturated monoenic acids with carbon chain lengths from C12 to C22.ResultsIn all hypertensive patients is disturbed lipid FA composition of erythrocytes. The patients with a normal level of serum lipids revealed deficiency of polyunsaturated acids n6-linoleic (18:2 n6), arachidonic (20:4 n6), dokozatetraenic 14,4% (22:4 n6). The patients with dislipidemia installed more profound restructuring of the lipid matrix of the membrane of erythrocytes. A decrease in polyunsaturated fatty acids family n3: dokozapentaenovoy (22:5 n3), docosahexaenoic PUFA (22:6 n3), the total value of n3 PUFA in 1,3 times was revealed.ConclusionThus, modification of erythrocyte FA are fairly subtle indicator of pathology of lipid metabolism, which manifest themselves much earlier than changes in the lipoprotein of blood plasma.

【 授权许可】

Unknown   
© Novgorodtseva et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.