Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss

Lipids in Health and Disease

Short Paper

James D LeCheminant¹  Joseph E Donnelly²  Eric C Westman³  Mary C Vernon⁴  Bryan K Smith⁵ 

[1] Brigham Young University, 269 SFH, 84606, Provo, UT, USA;Center for Physical Activity and Weight Management, The University of Kansas, 1301 Sunnyside Avenue, 66045, Lawrence, Kansas, USA;Department of Medicine, Duke University Medical Center, 4020 N Roxboro Street, 27704, Durham, North Carolina, USA;Private Practice, 21624 Midland Drive, Shawnee, Kansas, 66218, Lawrence, Kansas, USA;The University of Kansas, 1301 Sunnyside Avenue, 66045, Lawrence, Kansas, USA;

关键词: Weight Maintenance;    Carbohydrate Consumption;    Lipoprotein Subclass;    Lipid Subclass;    Large VLDL;   

DOI  :  10.1186/1476-511X-9-54

 received in 2010-03-26, accepted in 2010-06-01,  发布年份 2010

来源: Springer

【 摘 要 】

ObjectivesThis study compared LDL, HDL, and VLDL subclasses in overweight or obese adults consuming either a reduced carbohydrate (RC) or reduced fat (RF) weight maintenance diet for 9 months following significant weight loss.MethodsThirty-five (21 RC; 14 RF) overweight or obese middle-aged adults completed a 1-year weight management clinic. Participants met weekly for the first six months and bi-weekly thereafter. Meetings included instruction for diet, physical activity, and behavior change related to weight management. Additionally, participants followed a liquid very low-energy diet of ~2092 kJ per day for the first three months of the study. Subsequently, participants followed a dietary plan for nine months that targeted a reduced percentage of carbohydrate (~20%) or fat (~30%) intake and an energy intake level calculated to maintain weight loss. Lipid subclasses using NMR spectroscopy were analyzed prior to weight loss and at multiple intervals during weight maintenance.ResultsBody weight change was not significantly different within or between groups during weight maintenance (p > 0.05). The RC group showed significant increases in mean LDL size, large LDL, total HDL, large and small HDL, mean VLDL size, and large VLDL during weight maintenance while the RF group showed increases in total HDL, large and small HDL, total VLDL, and large, medium, and small VLDL (p < 0.05). Group*time interactions were significant for large and medium VLDL (p > 0.05).ConclusionSome individual lipid subclasses improved in both dietary groups. Large and medium VLDL subclasses increased to a greater extent across weight maintenance in the RF group.

【 授权许可】

CC BY   
© LeCheminant et al; licensee BioMed Central Ltd. 2010