The MicroRNA-148/152 Family: Multi-faceted Players

Molecular Cancer

Review

Zhen-Ning Wang¹  Yong-Xi Song¹  Yue Chen² 

[1] Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 110001, Shenyang, P. R. China;Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 110001, Shenyang, P. R. China;Department of Colorectal Surgery, Liao Ning Cancer Hospital & Institute, 110042, Shenyang, P. R. China;

关键词: miR-148/152 family;    Disease;    Normal tissue;   

DOI  :  10.1186/1476-4598-12-43

 received in 2013-02-20, accepted in 2013-05-14,  发布年份 2013

来源: Springer

【 摘 要 】

MicroRNAs(miRNA) are noncoding RNAs of about 19–23 nucleotides that are crucial for many biological processes. Members of the microRNA-148/152(miR-148/152) family, which include microRNA-148a(miR-148a), microRNA-148b(miR-148b), and microRNA-152(miR-152), are expressed differently in tumor and nontumor tissues and are involved in the genesis and development of disease. Furthermore, members of the miR-148/152 family are important in the growth and development of normal tissues. Members of the miR-148/152 family regulate target genes and are regulated by methylation of CPG islands. In this review, we report recent studies on the expression of members of the miR-148/152 family, methylation of CPG islands, and their target genes in different diseases, as well as in normal tissues.

【 授权许可】

Unknown   
© Chen et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.