Risk of mortality associated with respiratory syncytial virus and influenza infection in adults

BMC Infectious Diseases

Research Article

Jae Seok Park¹  Hyun Jung Kim¹  Sun Hyo Park¹  Yong Shik Kwon¹  Mi-Ae Kim¹  Sonila Dauti²  Won-Il Choi³  Choong Won Lee⁴  Mi Young Lee⁵ 

[1] Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea;Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea;Department of Allergology, Hospital Serive of Kavaje, Kavaje, Albania;Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea;Department of Internal Medicine, Keimyung University School of Medicine, 194 Dongsan-Dong, Jung-Gu, 700-712, Daegu, Korea;Department of Occupational & Environmental Medicine, Sungso Hospital, Andong, Republic of Korea;Department of Preventive Medicine, Keimyung University School of Medicine, Dongsan Hospital, Daegu, Republic of Korea;

关键词: Respiratory syncytial viruses;    Influenza, human;    Mortality;   

DOI  :  10.1186/s12879-017-2897-4

 received in 2017-04-10, accepted in 2017-12-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundRespiratory syncytial virus (RSV) infection constitutes a substantial disease burden in the general population. However, the risk of death for RSV infection has been rarely evaluated with confounders or comorbidities adjusted. We aimed to evaluate whether RSV infection is associated with higher mortality than seasonal influenza after adjusting for confounders and comorbidities and the effect of oseltamivir on the mortality in patients with influenza infection.MethodsA retrospective cohort study was conducted on adult (≥18 years) patients admitted to the emergency department and ward of a university teaching hospital for suspected viral infection during 2013–2015 (N = 3743). RSV infection was diagnosed by multiplex PCR (N = 87). Adults hospitalized for seasonal influenza during the study period were enrolled as a comparison group (n = 312). The main outcome was 20-day all-cause mortality.We used Cox proportional hazard regression analyses to calculate the relative risk of death.ResultsAdult patients were less likely to be diagnosed with RSV than with influenza (2.3 vs 8.3%, respectively), were older and more likely to be diagnosed with pneumonia, chronic obstructive pulmonary disease, hypoxemia, and bacterial co-infection. In patients with RSV infection, the 20-day all-cause mortality was higher than that for influenza, (18.4 vs 6.7%, respectively). RSV infection showed significantly higher risk of death compared to the seasonal influenza group, with hazard ratio, 2.32 (95% CI, 1.17–4.58). Oseltamivir had no significant effect on mortality in patients with influenza.ConclusionsRSV infection was significantly associated with a higher risk of death than seasonal influenza, adjusted for potential confounders and comorbidities.

【 授权许可】

CC BY   
© The Author(s). 2017