Alcohol and stroke: the splitters win again

BMC Medicine

Commentary

H. Nicole Tran¹  Arthur L. Klatsky² 

[1] Department of Medicine, Oakland Medical Center, Northern California Kaiser Permanente, Oakland, CA, USA;Division of Research, Northern California Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA;

关键词: Stroke;    Hemorrhagic stroke;    Ischemic stroke;    Alcohol drinking;    Epidemiology;    Risk factors;    Non-linear curves;    Confounding;   

DOI  :  10.1186/s12916-016-0750-z

 received in 2016-11-15, accepted in 2016-11-16,  发布年份 2016

来源: Springer

【 摘 要 】

Study of the relationships of alcohol drinking and risk of stroke can readily become mired in the labyrinthine interactions of drinking categorizations, non-linear associations, disparate cardiovascular conditions, and the heterogeneous types of stroke. This Commentary discusses the recent article by Larsson et al. (BMC Medicine 14:178, 2016). The authors split their material into separate meta-analyses of subarachnoid hemorrhage, intracerebral hemorrhage, and ischemic stroke, finding disparate alcohol–stroke relationships. Our Commentary pursues the disparity theme, using the lumpers versus splitters paradigm to explore several aspects of this complex area.Please see related article: http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0721-4.

【 授权许可】

CC BY   
© The Author(s). 2016