Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

BMC Biology

Commentary

Tania F de Koning-Ward¹  Paul R Gilson²  Brendan S Crabb³ 

[1] Deakin University, 3217, Waurn Ponds, Victoria, Australia;Macfarlane Burnet Institute for Medical Research and Public Health, 3004, Melbourne, Victoria, Australia;Monash University, 3800, Clayton, Victoria, Australia;Macfarlane Burnet Institute for Medical Research and Public Health, 3004, Melbourne, Victoria, Australia;The University of Melbourne, 3010, Melbourne, Victoria, Australia;Monash University, 3800, Clayton, Victoria, Australia;

关键词: Malaria;    Plasmodium;    Artemisinin;    Plasmodium Parasite;    Plasmodium Berghei;   

DOI  :  10.1186/1741-7007-9-21

 received in 2011-03-28, accepted in 2011-03-31,  发布年份 2011

来源: Springer

【 摘 要 】

The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identifying and validating new targets for intervention against malaria. But further improvements are still needed for the full power of genome-wide molecular genetic screens to be utilized in this organism.See research article: http://www.biomedcentral.com/1471-2164/12/155

【 授权许可】

CC BY   
© Crabb et al; licensee BioMed Central Ltd. 2011