Enhancing the effect of repetitive I-wave paired-pulse TMS (iTMS) by adjusting for the individual I-wave periodicity

BMC Neuroscience

Research Article

Arno Villringer¹  Sebastian Sewerin¹  Marco Taubert¹  Henning Vollmann¹  Patrick Ragert¹  Virginia Conde¹ 

[1] Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neurology, D-04103, Leipzig, Germany;

关键词: transcranial magnetic stimulation (TMS);    I-wave periodicity;    motor evoked potential (MEP);    primary motor cortex (M1);    corticospinal excitability;    paired-pulse stimulation;   

DOI  :  10.1186/1471-2202-12-45

 received in 2011-03-10, accepted in 2011-05-18,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundRepeated application of paired-pulse TMS over the primary motor cortex (M1) in human subjects with an inter-pulse interval (IPI) of 1.5 ms (iTMS1.5 ms) has been shown to significantly increase paired-pulse MEP (ppMEP) amplitudes during the stimulation period and increased single-pulse MEP amplitudes for up to 10 minutes after termination of iTMS.ResultsHere we show in a cross-over design that a modified version of the iTMS1.5 ms protocol with an I-wave periodicity adjusted to the individual I1-peak wave latency (iTMSadj) resulted in a stronger effect on ppMEPs relative to iTMS1.5 ms.ConclusionsBased on these findings, our results indicate that the efficiency of iTMS strongly depends on the individual choice of the IPI and that parameter optimization of the conventional iTMS1.5 ms protocol might improve the outcome of this novel non-invasive brain stimulation technique.

【 授权许可】

Unknown   
© Sewerin et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.