Enhancing the effect of repetitive I-wave paired-pulse TMS (iTMS) by adjusting for the individual I-wave periodicity

BMC Neuroscience

Patrick Ragert¹  Arno Villringer¹  Virginia Conde¹  Henning Vollmann¹  Marco Taubert¹  Sebastian Sewerin¹ 

[1] Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neurology, D-04103 Leipzig, Germany

关键词: paired-pulse stimulation;    corticospinal excitability;    primary motor cortex (M1);    motor evoked potential (MEP);    I-wave periodicity;    transcranial magnetic stimulation (TMS);   

Others  :  1174786
DOI  :  10.1186/1471-2202-12-45

 received in 2011-03-10, accepted in 2011-05-18,  发布年份 2011

【 摘 要 】

Background

Repeated application of paired-pulse TMS over the primary motor cortex (M1) in human subjects with an inter-pulse interval (IPI) of 1.5 ms (iTMS_{1.5 ms}) has been shown to significantly increase paired-pulse MEP (ppMEP) amplitudes during the stimulation period and increased single-pulse MEP amplitudes for up to 10 minutes after termination of iTMS.

Results

Here we show in a cross-over design that a modified version of the iTMS_{1.5 ms} protocol with an I-wave periodicity adjusted to the individual I1-peak wave latency (iTMS_adj) resulted in a stronger effect on ppMEPs relative to iTMS_{1.5 ms}.

Conclusions

Based on these findings, our results indicate that the efficiency of iTMS strongly depends on the individual choice of the IPI and that parameter optimization of the conventional iTMS_{1.5 ms} protocol might improve the outcome of this novel non-invasive brain stimulation technique.

【 授权许可】

   
2011 Sewerin et al; licensee BioMed Central Ltd.

【 图 表 】

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