Epigallocatechin-3-gallate and cancer: focus on the role of microRNAs

Cancer Cell International

Review

Meiling Bai¹  Zatollah Asemi²  Zhiguang Sun³  Chunguang Wang³  Nan Yao³  Aiting Zhang³  Shengyu Guo³ 

[1] Basic Medical College of Hebei North University, 075000, Zhang Jiakou, Hebei, China;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran;The First Affiliated Hospital of Hebei North University, 075000, Zhang Jiakou, Hebei, China;

关键词: Cancer;    Epigallocatechin-3-gallate;    Epigenetic;    MicroRNAs;    Molecular pathways;   

DOI  :  10.1186/s12935-023-03081-8

 received in 2023-07-26, accepted in 2023-09-21,  发布年份 2023

来源: Springer

【 摘 要 】

MicroRNAs (miRNAs) are a group of small non-coding RNAs that affect gene expression. The role of miRNAs in different types of cancers has been published and it was shown that several miRNAs are inappropriately expressed in different cancers. Among the mechanisms that can cause this lack of proper expression are epigenetics, chromosomal changes, polymorphisms or defects in processing proteins. Recent research shows that phytochemicals, including epigallocatechin-3-gallate (EGCG), exert important epigenetic-based anticancer effects such as pro-apoptotic or anti proliferative through miRNA gene silencing. Given that EGCG is able to modulate a variety of cancer-related process i.e., angiogenesis, proliferation, metastasis and apoptosis via targeting various miRNAs such as let-7, miR-16, and miR-210. The discovery of new miRNAs and the differences observed in their expression when exposed to EGCG provides evidence that targeting these miRNAs may be beneficial as a form of treatment. In this review, we aim to provide an overview, based on current knowledge, on how phytochemicals, including epigallocatechin-3-gallate, can be considered as potential miRNAs modulator to improve efficacy of current cancer treatments.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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