An Exploratory Descriptive Study of Antimicrobial Resistance Patterns of Staphylococcus Spp. Isolated from Horses Presented at a Veterinary Teaching Hospital

BMC Veterinary Research

Research Article

James Wabwire Oguttu¹  Agricola Odoi²  Daniel Nenene Qekwana³ 

[1] Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida Science Campus, Johannesburg, South Africa;Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida Science Campus, Johannesburg, South Africa;Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, USA;Section Veterinary Public Health, Department of Paraclinical Sciences, Faculty of Veterinary Sciences, University of Pretoria, Pretoria, South Africa;

关键词: Horse;    Staphylococcus aureus;    Staphylococcus pseudintemedius;    Staphylococcus epidermidis;    Staphylococcus chromogens;    Antimicrobial resistance;    Multi-drug resistance;    MDR;    Gauteng;    South Africa;   

DOI  :  10.1186/s12917-017-1196-z

 received in 2016-12-27, accepted in 2017-08-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAntimicrobial resistant Staphylococcus are becoming increasingly important in horses because of the zoonotic nature of the pathogens and the associated risks to caregivers and owners. Knowledge of the burden and their antimicrobial resistance patterns are important to inform control strategies. This study is an exploratory descriptive investigation of the burden and antimicrobial drug resistance patterns of Staphylococcus isolates from horses presented at a veterinary teaching hospital in South Africa.MethodsRetrospective laboratory clinical records of 1027 horses presented at the University of Pretoria veterinary teaching hospital between 2007 and 2012 were included in the study. Crude and factor-specific percentages of Staphylococcus positive samples, antimicrobial resistant (AMR) and multidrug resistant (MDR) isolates were computed and compared across Staphylococcus spp., geographic locations, seasons, years, breed and sex using Chi-square and Fisher’s exact tests.ResultsOf the 1027 processed clinical samples, 12.0% were Staphylococcus positive. The majority of the isolates were S. aureus (41.5%) followed by S. pseudintermedius (14.6%). Fifty-two percent of the Staphylococcus positive isolates were AMR while 28.5% were MDR. Significant (p < 0.05) differences in the percentage of samples with isolates that were AMR or MDR was observed across seasons, horse breeds and Staphylococcus spp. Summer season had the highest (64.3%) and autumn the lowest (29.6%) percentages of AMR isolates. Highest percentage of AMR samples were observed among the Boerperds (85.7%) followed by the American saddler (75%) and the European warm blood (73.9%). Significantly (p < 0.001) more S. aureus isolates (72.5%) were AMR than S. pseudintermedius isolates (38.9%). Similarly, significantly (p < 0.001) more S. aureus (52.9%) exhibited MDR than S. pseudintermedius (16.7%). The highest levels of AMR were towards β-lactams (84.5%) followed by trimethoprim/sulfamethoxazole (folate pathway inhibitors) (60.9%) while the lowest levels of resistance were towards amikacin (14.%).ConclusionsThis exploratory study provides useful information to guide future studies that will be critical for guiding treatment decisions and control efforts. There is a need to implement appropriate infection control, and judicious use of antimicrobials to arrest development of antimicrobial resistance. A better understanding of the status of the problem is a first step towards that goal.

【 授权许可】

CC BY   
© The Author(s). 2017