Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma

Respiratory Research

Letter to the Editor

Satyanarayana Maddi¹  Thomas Southworth¹  Umme Kolsum²  Dave Singh²  Arjun Ravi²  Paul Hitchen³ 

[1] Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, M23 9QZ, Manchester, UK;Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, M23 9QZ, Manchester, UK;The Medicines Evaluation Unit, M23 9QZ, Manchester, UK;The Medicines Evaluation Unit, M23 9QZ, Manchester, UK;

关键词: Eosinophils;    COPD;    Asthma COPD overlap;    ACOS;   

DOI  :  10.1186/s12931-017-0559-0

 received in 2017-02-28, accepted in 2017-04-20,  发布年份 2017

来源: Springer

【 摘 要 】

Eosinophilic COPD appears to be a distinct patient subgroup with an increased corticosteroid response. Eosinophilic COPD has been labelled as part of the asthma COPD overlap syndrome (ACOS). We compared the clinical characteristics of eosinophilic COPD patients (without any clinical history of asthma) and COPD patients with a childhood history of asthma. COPD patients with asthma were characterised by more allergies and more exacerbations, but less eosinophilic inflammation. While terms such as “ACOS” are used to “lump” patients together, we report distinct differences between eosinophilic COPD and COPD patients with asthma, and propose that these groups should be split rather than lumped.

【 授权许可】

CC BY   
© The Author(s). 2017