VERMONT: Visualizing mutations and their effects on protein physicochemical and topological property conservation

BMC Proceedings

Research

Flávia F Aburjaile¹  Yussif T Barcelos²  Wagner Meira Jr²  Raquel C de Melo-Minardi²  Valdete M Gonçalves-Almeida²  Sabrina A Silveira²  Alexandre V Fassio³  Laerte M Rodrigues³  Elisa B de Lima³ 

[1] Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil;Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil;Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil;Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil;

关键词: Mutation;    Visualization;    Molecular Structure and Function;    Bioinformatics;    Network Analysis;   

DOI  :  10.1186/1753-6561-8-S2-S4

来源: Springer

【 摘 要 】

In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based sequence alignments and integrate several structural parameters that should aid biologists in gaining insight into possible consequences of mutations. VERMONT allowed us to identify patterns of position-specific properties as well as exceptions that may help predict whether specific mutations could damage protein function.

【 授权许可】

CC BY   
© Silveira et al.; licensee BioMed Central Ltd. 2014