VERMONT: Visualizing mutations and their effects on protein physicochemical and topological property conservation

BMC Proceedings

Raquel C de Melo-Minardi¹  Wagner Meira Jr¹  Laerte M Rodrigues²  Flávia F Aburjaile²  Yussif T Barcelos¹  Elisa B de Lima²  Valdete M Gonçalves-Almeida¹  Alexandre V Fassio²  Sabrina A Silveira¹ 

[1] Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil;Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil

关键词: Network Analysis;    Bioinformatics;    Molecular Structure and Function;    Visualization;    Mutation;   

Others  :  1090953
DOI  :  10.1186/1753-6561-8-S2-S4

【 摘 要 】

In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based sequence alignments and integrate several structural parameters that should aid biologists in gaining insight into possible consequences of mutations. VERMONT allowed us to identify patterns of position-specific properties as well as exceptions that may help predict whether specific mutations could damage protein function.

【 授权许可】

   
2014 Silveira et al.; licensee BioMed Central Ltd.

【 图 表 】

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