The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions

BMC Cardiovascular Disorders

Research Article

Ahmet Avci¹  Bulent Behlul Altunkeser¹  Ahmet Yilmaz¹  Kenan Demir¹  Fikret Keles¹  Ahmet Ersecgin¹ 

[1] Faculty of Medicine Cardiology Department, Selcuk University, Konya, 42075, Turkey;

关键词: Chronic total occlusions;    Neutrophil-to-lymphocyte ratio;    SYNTAX score;   

DOI  :  10.1186/1471-2261-14-130

 received in 2014-07-10, accepted in 2014-09-23,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundNeutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).MethodsThe study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.ResultsNLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68–0.81), with a specificity of 69.3% and a sensitivity of 61%.ConclusionNLR may be useful as a marker of CTO.

【 授权许可】

CC BY   
© Demir et al.; licensee BioMed Central Ltd. 2014