The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions

BMC Cardiovascular Disorders

Ahmet Ersecgin¹  Fikret Keles¹  Ahmet Yilmaz¹  Bulent Behlul Altunkeser¹  Ahmet Avci¹  Kenan Demir¹ 

[1] Faculty of Medicine Cardiology Department, Selcuk University, 42075 Konya, Turkey

关键词: SYNTAX score;    Neutrophil-to-lymphocyte ratio;    Chronic total occlusions;   

Others  :  1088442
DOI  :  10.1186/1471-2261-14-130

 received in 2014-07-10, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).

Methods

The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.

Results

NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68–0.81), with a specificity of 69.3% and a sensitivity of 61%.

Conclusion

NLR may be useful as a marker of CTO.

【 授权许可】

   
2014 Demir et al.; licensee BioMed Central Ltd.

【 图 表 】

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