Journal of Cardiovascular Magnetic Resonance | |
Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study | |
Research | |
Keld E Sørensen1  Klavs W Hansen2  Alfred Hager3  Arne Hørlyck4  Jens S Christiansen5  Britta E Hjerrild5  Claus H Gravholt5  Kristian H Mortensen5  Niels H Andersen6  Erik Lundorf7  Erik M Pedersen7  | |
[1] Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, DK-8200, Aarhus N, Denmark;Department of Medicine, Silkeborg Centralsygehus, DK-8600, Silkeborg, Denmark;Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, D-80636, München, Germany;Department of Radiology, Skejby Sygehus, Århus University Hospital, DK-8200, Aarhus N, Denmark;Medical Department M (Endocrinology and Diabetes) and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, DK-8000, Aarhus C, Denmark;Medical Department M (Endocrinology and Diabetes) and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, DK-8000, Aarhus C, Denmark;Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, DK-8200, Aarhus N, Denmark;The MR Centre, Skejby Sygehus, Aarhus University Hospital, DK-8200, Aarhus N, Denmark; | |
关键词: Cardiovascular Magnetic Resonance; Body Surface Area; Aortic Dissection; Turner Syndrome; Bicuspid Aortic Valve; | |
DOI : 10.1186/1532-429X-12-12 | |
received in 2009-08-16, accepted in 2010-03-11, 发布年份 2010 | |
来源: Springer | |
【 摘 要 】
BackgroundTo investigate aortic dimensions in women with Turner syndrome (TS) in relation to aortic valve morphology, blood pressure, karyotype, and clinical characteristics.Methods and resultsA cross sectional study of 102 women with TS (mean age 37.7; 18-62 years) examined by cardiovascular magnetic resonance (CMR- successful in 95), echocardiography, and 24-hour ambulatory blood pressure. Aortic diameters were measured by CMR at 8 positions along the thoracic aorta. Twenty-four healthy females were recruited as controls. In TS, aortic dilatation was present at one or more positions in 22 (23%). Aortic diameter in women with TS and bicuspid aortic valve was significantly larger than in TS with tricuspid valves in both the ascending (32.4 ± 6.7 vs. 26.0 ± 4.4 mm; p < 0.001) and descending (21.4 ± 3.5 vs. 18.8 ± 2.4 mm; p < 0.001) aorta. Aortic diameter correlated to age (R = 0.2 - 0.5; p < 0.01), blood pressure (R = 0.4; p < 0.05), a history of coarctation (R = 0.3; p = 0.01) and bicuspid aortic valve (R = 0.2-0.5; p < 0.05). Body surface area only correlated with descending aortic diameter (R = 0.23; p = 0.024).ConclusionsAortic dilatation was present in 23% of adult TS women, where aortic valve morphology, age and blood pressure were major determinants of the aortic diameter.
【 授权许可】
CC BY
© Hjerrild et al; licensee BioMed Central Ltd. 2010
【 预 览 】
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