Dilation of the ascending aorta in Turner syndrome - a prospective cardiovascular magnetic resonance study

Journal of Cardiovascular Magnetic Resonance

Research

Niels H Andersen¹  Keld Ejvind Sørensen¹  Britta E Hjerrild²  Kirstine Stochholm²  Kristian H Mortensen²  Claus H Gravholt²  Jens S Christiansen²  Erik M Pedersen³  Arne Hørlyck⁴  Erik Lundorf⁵ 

[1] Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark;Department of Endocrinology and Internal Medicine (MEA) and Medical Research Laboratories, Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark;Department of Radiology, Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark;Department of Radiology, Aarhus University Hospital Skejby, Aarhus, Denmark;The MR Centre, Aarhus University Hospital Skejby, Aarhus, Denmark;

关键词: Cardiovascular Magnetic Resonance;    Aortic Dissection;    Turner Syndrome;    Bicuspid Aortic Valve;    Aortic Diameter;   

DOI  :  10.1186/1532-429X-13-24

 received in 2010-12-30, accepted in 2011-04-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe risk of aortic dissection is 100-fold increased in Turner syndrome (TS). Unfortunately, risk stratification is inadequate due to a lack of insight into the natural course of the syndrome-associated aortopathy. Therefore, this study aimed to prospectively assess aortic dimensions in TS.MethodsEighty adult TS patients were examined twice with a mean follow-up of 2.4 ± 0.4 years, and 67 healthy age and gender-matched controls were examined once. Aortic dimensions were measured at nine predefined positions using 3D, non-contrast and free-breathing cardiovascular magnetic resonance. Transthoracic echocardiography and 24-hour ambulatory blood pressure were also performed.ResultsAt baseline, aortic diameters (body surface area indexed) were larger at all positions in TS. Aortic dilation was more prevalent at all positions excluding the distal transverse aortic arch. Aortic diameter increased in the aortic sinus, at the sinotubular junction and in the mid-ascending aorta with growth rates of 0.1 - 0.4 mm/year. Aortic diameters at all other positions were unchanged. The bicuspid aortic valve conferred higher aortic sinus growth rates (p < 0.05). No other predictors of aortic growth were identified.ConclusionA general aortopathy is present in TS with enlargement of the ascending aorta, which is accelerated in the presence of a bicuspid aortic valve.

【 授权许可】

CC BY   
© Mortensen et al; licensee BioMed Central Ltd. 2011