Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats

Lipids in Health and Disease

Research

Elizabethe Adriana Esteves¹  Liliane Vanessa Costa-Pereira¹  Ana Maria Alves¹  Flávio de Castro Magalhães¹  Lauane Gomes Moreno¹  Dirceu Sousa Melo¹  Paulo Henrique Evangelista Silva¹  Marco Fabrício Dias-Peixoto¹  Lidiane Guedes Oliveira¹  Mayara Medeiros de Freitas Carvalho² 

[1] Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia (SBFis) – Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM, Rodovia MGT 367 – Km 583, n° 5000, Alto da Jacuba, CEP: 39100-000, Diamantina, MG, Brazil;Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto - Campus Universitário, Morro do Cruzeiro, CEP: 35400-000, Ouro Preto, MG, Brazil;

关键词: Caryocar brasiliense;    Monounsaturated fatty acids;    Oleic acid;    Carotenoids;    Cardiac function;    Cardiovascular disease;   

DOI  :  10.1186/s12944-017-0422-9

 received in 2016-12-21, accepted in 2017-01-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCaryocar brasiliense (pequi) oil is high in monounsaturated fat acids (MUFA), especially oleic, and in carotenoids, which have been associated with protection against cardiovascular disease. However, this food is poorly studied in this context, especially in the cardiac function. Therefore, we investigated the effects of a long-term intake of pequi oil in systemic cardiovascular risk factors and in the ex vivo cardiac function of rats.MethodsPreviously, we determined fatty acids and carotenoids in pequi oil. Next, male rats were divided in C – control group feed a standard diet, and PO – pequi oil group fed the same diet added pequi oil (+2.25 g.100 g−1). After 15 weeks, plasma lipids, glucose, insulin, blood pressure, heart rate, hepatic lipids were accessed and visceral fat pads were harvested. Hearts were used for the ex vivo cardiac function, histologic assays, SERCA2a and phospholanban (PLB) determinations.ResultsIn agreement with scientific data, pequi oil had expressive amounts MUFA, especially oleic acid, and carotenoids. Hepatic triglycerides (TG) were reduced by pequi oil intake (p < 0.05). All others cardiovascular risk factors were not changed. The intrinsic heart rate was lower in PO group (p < 0.05). SERCA2a content was higher in this group (p < 0.05), without affecting PLB. Also, SERCA2a/PLB ratio increased in PO group (p < 0.05).ConclusionPequi oil intake improved cardiac function ex vivo, despite no significant changes in systemic cardiovascular risk factors. The higher lipid offer in pequi oil diet, its composition in oleic acid and carotenoids could be related to those effects.

【 授权许可】

CC BY   
© The Author(s). 2017