The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion

Lipids in Health and Disease

Research

Katiene Macêdo de Oliveira¹  Victor Hugo Rezende Duarte¹  André Ducati Luchessi¹  Raul Hernandes Bortolin¹  Adriana Augusto Rezende¹  Vivian Nogueira Silbiger¹  Jéssica Nayara Góes de Araújo¹  Severina Carla Vieira Cunha Lima²  Dan Linetzky Waitzberg³  Rosário Domingues Hirata⁴  Mario Hiroyuki Hirata⁴  Juliana Marinho de Oliveira⁵  Antonio Augusto Ferreira Carioca⁶  Mychelle Kytchia Rodrigues Nunes Duarte⁷ 

[1] Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, CEP: 59014-520, Natal, Rio Grande do Norte, Brazil;Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil;Faculty of Medicine (LIM-35), University of São Paulo, São Paulo, Brazil;Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil;Hospital Universitário Onofre Lopes, Federal University of Rio Grande do Norte, Natal, Brazil;Nutrition Department, School of Public Health, University of São Paulo, São Paulo, Brazil;Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil;

关键词: Oleic acid;    ECHDC3;    Friesinger index;    Monounsaturated fatty acids;    Cardiovascular diseases;   

DOI  :  10.1186/s12944-016-0312-6

 received in 2016-07-01, accepted in 2016-08-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion.MethodsFifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated.ResultsElevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1.2 fold higher in patients with low lesion than in patients without lesion (p = 0.020), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.023).ConclusionIncreased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.

【 授权许可】

CC BY   
© The Author(s). 2016