Oncological prognosis and morbidity of hepatectomy in elderly patients with hepatocellular carcinoma: a propensity score matching and multicentre study

BMC Surgery

Research

Dong Jiang¹  Xin-Yuan Hu¹  Jiang-Ming Chen¹  Fu-Xiao Ma¹  Xiao-Ping Geng¹  Fu-Bao Liu¹  Ping-Chuan Ma¹  Zi-Xiang Chen¹  Chuan-Ming Wang¹  Jin-Liang Ma²  Hui Hou³ 

[1] Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 230022, Anhui, China;Department of General Surgery, The First Affiliated Hospital of University of Science and Technology, 230031, Anhui, China;Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, 230601, Anhui, China;

关键词: Hepatocellular carcinoma;    Hepatectomy;    Elderly patients;    Propensity score matching;    Prognosis;    Cancer-specific survival;   

DOI  :  10.1186/s12893-023-02230-0

 received in 2023-03-23, accepted in 2023-10-12,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeWith increasing life expectancy, the number of elderly patients (≥ 65 years) with hepatocellular carcinoma (HCC) has steadily increased. Hepatectomy remains the first-line treatment for HCC patients. However, the prognosis of hepatectomy for elderly patients with HCC remains unclear.MethodsClinical and follow-up data from 1331 HCC patients who underwent surgery between 2008 and 2020 were retrospectively retrieved from a multicentre database. Patients were divided into elderly (≥ 65 years) and non-elderly (< 65 years) groups, and PSM was used to balance differences in the baseline characteristics. The postoperative major morbidity and cancer-specific survival (CSS) of the two groups were compared and the independent factors that were associated with the two study endpoints were identified by multivariable regression analysis.ResultsOf the 1331 HCC patients enrolled in this study, 363 (27.27%) were elderly, while 968 (72.73%) were not. After PSM, 334 matched samples were obtained. In the propensity score matching (PSM) cohort, a higher rate of major morbidity was found in elderly patients (P = 0.040) but the CSS was similar in the two groups (P = 0.087). Multivariate analysis revealed that elderly age was not an independent risk factor associated with high rates of major morbidity (P = 0.117) or poor CSS (P = 0.873). The 1-, 3- and 5-year CSS rates in the elderly and non-elderly groups were 91.0% versus 86.2%, 71.3% versus 68.8% and 55.9% versus 58.0%, respectively. Preoperative alpha fetoprotein (AFP) level, Child‒Pugh grade, intraoperative blood transfusion, extended hemi hepatectomy, and tumour diameter could affect the postoperative major morbidity and preoperative AFP level, cirrhosis, Child‒Pugh grade, macrovascular invasion, microvascular invasion (MVI), satellite nodules, and tumor diameter were independently and significantly associated with CSS.ConclusionAge itself had no significant effect on the prognosis of elderly patients with HCC after hepatectomy. Hepatectomy can be safely performed in elderly patients after cautious perioperative management.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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