Sero-epidemiological evaluation of Plasmodium falciparum malaria in Senegal

Malaria Journal

Research

Marie Louise Tshibola Mbuyi¹  Roger Clément Kouly Tine²  Aïda Sadikh Badiane²  Magatte Ndiaye²  Mame Cheikh Seck²  Annie Abiola²  Oumar Ndir²  Doudou Sow²  Amy Colé Lô²  Mouhamadou Ndiaye²  Oumar Faye²  Khadime Sylla²  Babacar Faye²  Jean Louis A N’Diaye²  Daouda Ndiaye²  Aïssatou Sarr²  Ibrahima Diouf²  Thérèse Dieng²  Yémou Dieng²  Oumar Gaye² 

[1] Département de Parasitologie-Mycologie, Université des Sciences de la Santé, Libreville, Gabon;Service de Parasitologie-Mycologie, Faculté de Médecine, Pharmacie et Odontologie, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal;

关键词: Malaria;    Plasmodium falciparum;    Serology;    Epidemiology;    Senegal;   

DOI  :  10.1186/s12936-015-0789-x

 received in 2015-01-30, accepted in 2015-07-01,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundIn Senegal, a significant decrease of malaria transmission intensity has been noted the last years. Parasitaemia has become lower and, therefore, more difficult to detect by microscopy. In the context of submicroscopic parasitaemia, it has become relevant to rely on relevant malaria surveillance tools to better document malaria epidemiology in such settings. Serological markers have been proposed as an essential tool for malaria surveillance. This study aimed to evaluate the sero-epidemiological situation of Plasmodium falciparum malaria in two sentinel sites in Senegal.MethodsCross-sectional surveys were carried out in Velingara (south Senegal) and Keur Soce (central Senegal) between September and October 2010. Children under 10 years old, living in these areas, were enrolled using two-level, random sampling methods. P. falciparum infection was diagnosed using microscopy. P. falciparum antibodies against circumsporozoite protein (CSP), apical membrane protein (AMA1) and merozoite surface protein 1_42 (MSP1_42) were measured by ELISA method. A stepwise logistic regression analysis was done to assess factors associated with P. falciparum antibodies carriage.ResultsA total of 1,865 children under 10 years old were enrolled. The overall falciparum malaria prevalence was 4.99% with high prevalence in Velingara of 10.03% compared to Keur Soce of 0.3%. Symptomatic malaria cases (fever associated with parasitaemia) represented 17.37%. Seroprevalence of anti-AMA1, anti-MSP1_42 and anti-CSP antibody was 38.12, 41.55 and 40.38%, respectively. The seroprevalence was more important in Velingara and increased with age, active malaria infection and area of residence.ConclusionThe use of serological markers can contribute to improved malaria surveillance in areas with declining malaria transmission. This study provided useful baseline information about the sero-epidemiological situation of malaria in Senegal and can contribute to the identification of malaria hot spots in order to concentrate intervention efforts.Trial registration number: PACTR201305000551876 (http://www.pactr.org).

【 授权许可】

CC BY   
© Sylla et al. 2015