Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study

BMC Emergency Medicine

Research

Zhihua Shi¹  Ziwei Deng¹  Ye Deng¹  Zhenxing Duan²  Jin Wang²  Jianliang Zhou²  Tao Jiang²  Xiang Zhao³  Yuanlu Shu³  Chengfeng Qiu⁴ 

[1] Clinical Pharmacy Department, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Emergency Department, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Evidence-based Medicine and Clinical Center, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Evidence-based Medicine and Clinical Center, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;Clinical Pharmacy Department, The First People’s Hospital of Huaihua, 418000, Huaihua, P.R. China;School of Basic Medical Sciences, University of South China, 421000, Hengyang, P.R. China;

关键词: PCSK9;    Mortality;    Sepsis;   

DOI  :  10.1186/s12873-023-00896-6

 received in 2022-12-30, accepted in 2023-10-18,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesPro-protein convertase subtilisin/kexin 9 (PCSK9) decreases the clearance of the pathogenic lipids, supporting the potential role of PCSK9 in the prognosis of sepsis.MethodsIn this prospective cohort study, patients with sepsis were consecutively recruited from 1 to 2020 to 30 September 2021 at the First People’s Hospital of Huaihua, China. All the eligible patients were categorized into low-PCSK9 and high-PCSK9 groups, based on their PCSK9 levels at admission. Time-dependent receiver operating characteristic curves and Cox proportional hazards regression were used to evaluate the association between PCSK9 level and 28-day mortality of sepsis.ResultsOf the 203 enrolled patients, 56 (27.59%) died during the 28-day follow-up. The PCSK9 level was positively related to the C-reactive protein level. The cut-off point of PCSK9 levels for 28-day mortality risk was 370 ng/ml. Through comparison between high-PCSK9 (> 370 ng/ml) with low-PCSK9 (≤ 370 ng/ml) groups, the adjusted HR for mortality was 2.56 (95% CI: 1.25–5.23, p = 0.01).ConclusionsThe 28-day mortality of sepsis increased significantly as the baseline circulating PCSK9 level exceeded 370 ng/ml, indicating circulating PCSK9 levels may be a potential biomarker to predict the prognosis of sepsis.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 4