Relationship between community walking ability and in-hospital mortality in elderly patients with sepsis: a single-center retrospective cohort study

Journal of Intensive Care

Ryohei Yamamoto¹  Ryo Ueno¹  Yoshiro Hayashi¹  Seibi Kobara²  Atsushi Shiraishi³ 

[1] 0000 0004 0378 2140, grid.414927.d, Department of Intensive Care Medicine, Kameda Medical Center, 929, Higashi-cho, 296-0041, Kamogawa, Chiba, Japan;0000 0004 0378 2140, grid.414927.d, Department of Rehabilitation, Kameda Medical Center, 929, Higashi-cho, 296-0041, Kamogawa, Chiba, Japan;0000 0004 0378 2140, grid.414927.d, Emergency and Trauma Center, Kameda Medical Center, 929, Higashi-cho, 296-0041, Kamogawa, Chiba, Japan;

关键词: Adults;    Frailty;    Mortality;    Sepsis;   

DOI  :  10.1186/s40560-019-0385-1

来源: publisher

【 摘 要 】

PurposeTo examine the association of a simple frailty assessment, Life Space (LS), with in-hospital mortality in elderly patients with sepsis.MethodsWe used data from a single hospital between 2014 and 2017. We included elderly patients (age ≥ 65 years) admitted to the intensive care unit (ICU) with sepsis, as defined by sepsis-3 criteria. Frailty assessment was based on a patient’s ability to independently go out of the house before the ICU admission. We termed this dichotomous score as Life Space. The primary outcome was in-hospital mortality. Logistic regression was used to investigate the association of LS with each outcome after adjusting for age, sex, and Sequential Organ Failure Assessment score.ResultsOf the 335 participants included in the final analysis, 121 (36%) were classified as frail. LS-positive patients had a higher in-hospital mortality (adjusted odds ratio (aOR) 2.32; 95% confidence interval (CI) 1.36–3.96; P = 0.002) than did LS-negative patients. We observed similar patterns in six sets of sensitivity analyses after accounting for different confounders. In subgroup analyses, significant interactions were observed in participants with versus those without treatment limitations (aOR 1.02 vs. 2.66, P for interaction = 0.042).ConclusionsIn this single-center study, frailty assessed by LS was independently associated with a higher in-hospital mortality.

【 授权许可】

CC BY