Effect of ABO blood group on postoperative overall survival and recurrence-free survival rate in patients with hepatocellular carcinoma after hepatectomy: a multi-center retrospective cohort study

BMC Surgery

Research

Pouya Ebrahimi¹  Mansour Bahardoust²  Adnan Tizmaghz³  Meisam Haghmoradi⁴  Safa Mousavi⁵  Maryam Najafirashed⁶  Maryam Zolfaghari Dehkharghani⁷  Mohsen Khaleghian⁸ 

[1] Ahvaz, Jundishapur University of Medical Sciences, Ahvaz, Iran;Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of General Surgery, School of Medicine, Iran University of Medical Sciences(IUMS), Tehran, Iran;Department of Orthopedic Surgery, Urmia University of Medical Sciences, Urmia, Iran;Department of Public Health, College of Health and Human Services, California State University, Fresno, CA, USA;School of Medicine, Iran University of Medical Sciences, Tehran, Iran;School of Public Health, Department of Health Care Administration and Policy, University of Nevada Las Vegas(UNLV), Las Vegas, NV, USA;Vascular Surgery Department of General Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;

关键词: Hepatocellular carcinoma;    Overall survival rate;    Recurrence-free survival;    ABO blood group;   

DOI  :  10.1186/s12893-023-02236-8

 received in 2023-07-06, accepted in 2023-10-16,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The survival rate after hepatectomy as the first line of treatment for HCC depends on various factors. This study evaluated the association of the ABO blood group and Rh with overall survival (OS) and Recurrence-free survival (RFS) rate after hepatectomy.MethodsThis multicenter retrospective cohort study reviewed the medical files of 639 HCC patients who underwent hepatectomy from 2010 to 2022 in three medical centers affiliated with the Iran University of Medical Sciences. Patient data, including demographic, clinical, tumor characteristics, and post-surgery outcomes, were collected by referring to the patient’s medical profiles. The Cox proportional hazard investigated the relationship between ABO blood group type and OS and RFS rate after hepatectomy.ResultsThe five-year OS and RFS rates were 25.4% and 18.7%, respectively. The five-year OS (Lok rank:40.89, P:0.001) and RFS rate in patients with blood type A were significantly lower than in non-A patients. (Lok rank:10.8, P:0.001) The multivariate Cox analysis showed that blood type A, age < 45 years, tumor size > 5 cm, Poor tumor differentiation, presence of metastasis, The number of involved lymph nodes ≤ 2, and serum Alpha-Fetoprotein)AFP( level ≥ 400 were significantly related to the decreased survival rate of HCC patients after hepatectomy (P < 0.05) There was no significant association between Rh with OS and RFS (P > 0.05).ConclusionBlood group type A, compared to non-A, can be associated with decreased OS and RFS rates in patients with HCC after hepatectomy.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 3