Ambient ozone exposure and children’s acute asthma in New York City: a case-crossover analysis

Environmental Health

Research

Jane Ellen Clougherty¹  Jessie Loving Carr Shmool¹  Jiang Zhou¹  Perry Elizabeth Sheffield² 

[1] Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 100 Technology Drive, 15219, Pittsburgh, PA, USA;Icahn School of Medicine at Mount Sinai, Box 1057, DPM, 1 Gustave L. Levy Pl., 10029, New York, NY, USA;

关键词: Air pollution;    Ozone;    Children;    Asthma;    Case-crossover;    Time-series;    Emergency department;    Hospitalization;   

DOI  :  10.1186/s12940-015-0010-2

 received in 2014-10-23, accepted in 2015-02-26,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundChildhood asthma morbidity has been associated with ambient ozone in case-crossover studies. Varying effects of ozone by child age and sex, however, have been less explored.MethodsThis study evaluates associations between ozone exposure and asthma emergency department visits and hospitalizations among boys and girls aged 5-17 years in New York City for the 2005-2011 warm season period. Time-stratified case-crossover analysis was conducted and, for comparison, time-series analysis controlling for season, day-of-week, same-day and delayed effects of temperature and relative humidity were also performed.ResultsWe found associations between ambient ozone levels and childhood asthma emergency department visits and hospitalizations in New York City, although the relationships varied among boys and girls and by age group. For an increase of interquartile range (0.013 ppm) in ozone, there was a 2.9-8.4% increased risk for boys and 5.4-6.5% for girls in asthma emergency department visits; and 8.2% increased risk for girls in hospitalizations. Among girls, we observed stronger associations among older children (10-13 and 14-17 year age groups). We did not observe significant modification by age for boys. Boys exhibited a more prompt response (lag day 1) to ozone than did girls (lag day 3), but significant associations for girls were retained longer, through lag day 6.ConclusionsOur study indicates significant variance in associations between short-term ozone concentrations and asthma events by child sex and age. Differences in ozone response for boys and girls, before and after puberty, may point towards both social (gendered) and biological (sex-linked) sources of effect modification.

【 授权许可】

CC BY   
© Sheffield et al.; licensee BioMed Central. 2015